Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect N acetylcysteine (NAC) is an important medication used in the management of acute liver failure, especially when it is caused by paracetamol (acetaminophen) overdose. , NAC works by replenishing Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing)