Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI Pathology Outlines Melanotic macule In the process of removing a Labial Melanotic Macule. A Labial Melanotic Macule is a well defined, oval, brown to black, flat patch on the central third of the lower lip, as seen Melanosis and Lentiginosis (benign) Vulvovaginal Disorders Pigmented Lesions of the Oral Mucosa Pocket Dentistry