A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona Glutathione Depletion in Mitochondrial Diseases Glutathione Reporter Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Frontiers Commentary: Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness?
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paracetamol and glutathione depletion Illustration of the effects of acetaminophen on glutathione,